One focused example of how genetic modification is applied in relation to Antisense therapy is cancer antisense therapy. In the past years, research has lead to a more cancer antisense therapy to target specific cellular proteins and genetic components. Antisense therapy uses oligonucleotides to help with a potential treatment strategy in the fight against cancer. When scientists developed nucleotides, they bind to the protein making a heteroduplex, which may help to destroy the cancer cells. The new genetically made strand of mRNA will now bind to the matching nucleotides of the cancer cells mRNA sense. Some of the 20 proteins that are targeted are Bcl-2, IT-ras and PKC-alpha. Even through much research is still needed to further make cancer antisense therapy more effective, a lot of discoveries over the past years have made antisense cancer therapy an effective choice as a treatment towards curing cancer.